p53 activation via pharmacologic MDM2 inhibition constrains exhaustion and enhances antitumor function of human CD8+ T cells

By afschroeder • October 31, 2026

Boix de Jesus A, Dao HB, Imani A, Rodriguez GA, Shehata MS, Chandran RR, Fine SA, Lim SY, To M, Lofftus SY, Pedroncelli N, Eilber FC, Gomperts BN, McCaw TR, Puig-Saus C, Crompton JG. p53 activation via pharmacologic MDM2 inhibition constrains exhaustion and enhances antitumor function of human CD8+ T cells. Front Immunol. 2026 Oct 16;17:1910235. doi: 10.3389/fimmu.2026.1910235. PMID: 42964330; PMCID: PMC13719607.

Tags: CD8, exhaustion, Hematology/Oncology, immunotherapy, metabolic fitness, p53, Post Doc, Publications, Pulmonary, Critical Care & Sleep Medicine, T-cell memory

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