Cullin-5 RING E3 ligase limits CD8⁺ T-cell persistence and effector responses during chronic antigen stimulation

By afschroeder • October 16, 2026

Saco JD, Karin D, Patten JJ, Bachl S, Ching C, Kale N, Fan Y, Medina E, Naser Al Deen N, Champhekar A, Kaelin WG, Schulman BA, Campbell KM, Carnevale J, Puig-Saus C, Ribas A. Cullin-5 RING E3 ligase limits CD8⁺ T-cell persistence and effector responses during chronic antigen stimulation. Cancer Immunol Res. 2026 Oct 15. doi: 10.1158/2326-6066.CIR-26-0181. Epub ahead of print. PMID: 42878659.

Tags: Hematology/Oncology, Publications

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