Systemic Allergic Reactions to mRNA COVID-19 Vaccines: A Randomized Placebo-controlled Trial

By afschroeder • October 14, 2026

Wheatley LM, Baker JR Jr, Adkinson NF, Gruchalla R, Schuler CF, Oberdoerster DA, Peters AT, Patel GB, Blumenthal KG, Wolfson AR, Robinson LB, Zoratti EM, Kim H, Phillips EJ, Stone CA Jr, Ramsey A, Jones SM, Jefferson AA, Kuruvilla M, Garcia-Lloret M, Ahn TS, Castells MC, Giannetti MP, Craig TJ, Henao MP, Casale TB, Pepper AN, Lanser BJ, Hoyte FCL, Mosnaim GS, Mehlis SL, Khan DA, Busse PJ, Schwartz LB, Sur S, Carr TF, Sobieszczyk ME, Peden DB, Dykewicz MS, Fasano MB, Nelson MR, Sindher SB, Moss MH, Kleiner G, Dispenza MC, Lai SK, Lucas AT, Li Z, Le QT, Altman MC, Cox MS, Steen H, Ahmed S, Viode A, Pucilowska J, Bainha K, Milne GL, Amin W, Feener EP, Lee D, Galvan MD, Busby JR, Romano PR, Schroeder K, David G, Calatroni A, Mason K, Nodzenski M, Wu A, Storm W, Brittain E, Dempsey C, Poyser J, Hamrah SD, Li L, Togias A. Systemic Allergic Reactions to mRNA COVID-19 Vaccines: A Randomized Placebo-controlled Trial. J Allergy Clin Immunol. 2026 Oct 13:S0091-6749(26)00716-5. doi: 10.1016/j.jaci.2026.09.024. Epub ahead of print. PMID: 42869401.

Tags: Allergy & Immunology, anaphylaxis mast cell disorders, COVID-19 mRNA vaccines, Mast Cell Activation, Publications, severe allergic reactions, systemic allergic reactions, vaccine hypersensitivity

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