Topoisomerase-Based CDH17 Antibody Drug Conjugates Overcome P-gp Resistance but Undergo Target Mediated Clearance in Colorectal Cancer

By afschroeder • October 6, 2026

O'Brien NA, Zhang J, Gong KW, McDermott MSJ, Hoffstrom B, Lu M, Liang M, Jia WP, Luo T, Madrid AM, Ayala R, Presta L, Larson SM, Glaspy JA, Slamon DJ. Topoisomerase-Based CDH17 Antibody Drug Conjugates Overcome P-gp Resistance but Undergo Target Mediated Clearance in Colorectal Cancer. Clin Cancer Res. 2026 Oct 5. doi: 10.1158/1078-0432.CCR-26-2010. Epub ahead of print. PMID: 42832380.

Tags: Hematology/Oncology, Publications

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