Temporal CRAC channel blockade modulates the MYC-MXD axis to attenuate autoimmune inflammation

By afschroeder • September 17, 2026

Wu B, Hasiakos S, Cokus S, Do M, Kaplan E, Pellegrini M, Sun Z, Kim RH, Srikanth S, Gwack Y. Temporal CRAC channel blockade modulates the MYC-MXD axis to attenuate autoimmune inflammation. Cell Rep. 2026 Sep 16;45(10):118017. doi: 10.1016/j.celrep.2026.118017. Epub ahead of print. PMID: 42747969.

Tags: autoimmunity, Ca2(+) signaling, CP: Immunology, CP: Metabolism, CRAC channels, Dermatology, effector T cells, immunometabolism, mitochondrial function in effector T cells, MYC-MXD axis, ORAI, Publications

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