Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors

By afschroeder • September 16, 2026

Zhu Y, Yu J, Kim YJ, Tian Y, Li Z, Chen Y, Lyu Z, Zhu E, Zhao AS, Ma N, Zhang C, Kramer A, Wilson M, Hon R, Wang YC, Lin S, Shen X, Hahn Z, Zhang Y, Wang A, Li YR, Yang L. Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors. Cell Rep Med. 2026 Sep 15;7(9):102998. doi: 10.1016/j.xcrm.2026.102998. Epub 2026 Aug 19. PMID: 42617602.

Tags: Allogeneic cell therapy, Cardiology/Epi, CRS, cytokine release syndrome, ESO-T cell, graft-versus-host disease, GVHD, hematopoietic stem and progenitor cell, HSPC, mono-specific T cell therapy, NY-ESO-1-specific cytotoxic T cell, Off-the-shelf, Publications, solid tumor therapy, transgenic TCR, tumor homing, Veterans Administration

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