Effect of Age and Age-Defined Menopausal Status on Linaclotide Efficacy and Safety in Adults With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation: Post Hoc Analyses of Phase 2b/3 Studies

Chang L, Staller K, Houghton LA, Yerneni N, Higgins S, Chen W, Wu J, Ford AC, Feuerstadt P, Brenner DM. Effect of Age and Age-Defined Menopausal Status on Linaclotide Efficacy and Safety in Adults With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation: Post Hoc Analyses of Phase 2b/3 Studies. Neurogastroenterol Motil. 2026 Sep;38(9):e70429. doi: 10.1111/nmo.70429. PMID: 42702764.


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