Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer’s Disease Severity

By afschroeder • August 29, 2026

Rentsendorj A, Vit JP, Hutton A, Koronyo Y, Shahin S, Robinson E, Barron E, Rodriguez A, Jallow O, Sheyn J, Gaire BP, Subedi L, Davis MR, Gnanabharathi B, Ljubimov AV, Graham SL, Gupta VK, Mirzaei M, Hawes D, Silm K, Black KL, Schneider LS, Sadun AA, Meyer JG, Fuchs DT, Koronyo-Hamaoui M. Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity. Adv Sci (Weinh). 2026 Aug 29:e00020. doi: 10.1002/advs.202600020. Epub ahead of print. PMID: 42666080; PMCID: PMC13525425.

Tags: Cedars Sinai DoM, Dementia, Endocrinology, excitatory synapse, MCI, N‐methyl‐D‐aspartate receptor subunit 2A, p75NTR, postsynaptic density protein 95, Publications, ubiquitin–proteasome system, vesicular glutamate transporter 1

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