Mitochondrial NCLX Couples Glucagon- and PDE2A-Dependent Signals to Regulate Hepatic Lipid Metabolism

By afschroeder • August 26, 2026

Assali EA, Taha M, Salhab A, Amer J, Krishnan KC, Kostic M, Veliova M, Brownstein AJ, Shirihai OS, Safadi R, Sekler I. Mitochondrial NCLX Couples Glucagon- and PDE2A-Dependent Signals to Regulate Hepatic Lipid Metabolism. Mol Metab. 2026 Aug 25:102433. doi: 10.1016/j.molmet.2026.102433. Epub ahead of print. PMID: 42641876.

Tags: Endocrinology, fatty acid oxidation, General Internal Medicine, Glucagon signaling, hepatic steatosis, lipolysis, MASLD (Metabolic dysfunction-associated steatotic liver disease), mitochondrial bioenergetics, mitochondrial calcium signaling, NCLX, PDE2A (Phosphodiesterase 2A), Publications, Resident

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