Inhibition of Acetyl-CoA-carboxylase induces endoplasmic reticulum stress and augments the efficacy of anti-cancer therapies

By afschroeder • August 4, 2026

Shan NL, Balinda H, Dai J, Wang Y, Lin HK, Marczyk M, Espinoza Campos G, Umlauf S, McDermott MSJ, Colorado I, Lang SM, Surovtseva YV, Feinman R, Slamon DJ, Blenman KRM, Yan Q, Muthusamy V, Brenner AJ, Pusztai L. Inhibition of Acetyl-CoA-carboxylase induces endoplasmic reticulum stress and augments the efficacy of anti-cancer therapies. Clin Cancer Res. 2026 Aug 3. doi: 10.1158/1078-0432.CCR-26-1028. Epub ahead of print. PMID: 42545737.

Tags: Hematology/Oncology, Publications

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