Intestinal lipase inhibition uncouples diet-induced obesity from MASH by remodeling the hepatic lipidome in mice

By afschroeder • July 28, 2026

Chan AP, Czernuszewicz TJ, Lai RW, Jarrett KE, Lau A, Warshan A, Cheng AS, Steel ME, Schmidt HM, Larios J, Little I, Rubert GE, Brearley-Sholto MC, Mamouei Z, Pesner JK, Hamad CD, Francis KP, Bernthal NM, Redente EF, Magyar CE, French SW, Wiliams KJ, Tarling EJ, de Aguiar Vallim TQ. Intestinal lipase inhibition uncouples diet-induced obesity from MASH by remodeling the hepatic lipidome in mice. J Lipid Res. 2026 Jul 27:101112. doi: 10.1016/j.jlr.2026.101112. Epub ahead of print. PMID: 42508572.

Tags: Absorption, Cardiology/Epi, Cholesterol, dietary fat, digestive, Endocrinology, lipase, lipidomics, Liver, polyunsaturated fatty acid, Post Doc, Publications, shear wave elastography, ultrasound

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