Sirexatamab in Combination with Bevacizumab and Chemotherapy as Second-Line Therapy for Advanced Colorectal Adenocarcinoma: the Phase II DeFianCe Trial

By afschroeder • July 24, 2026

Wainberg ZA, Lee KW, Kim JG, Devoe C, Strickler JH, Baum J, Jia C, Kagey MH, Sirard CA, Stein A, Scott AJ, Pelster M, Moehler M, Han SW. Sirexatamab in Combination with Bevacizumab and Chemotherapy as Second-Line Therapy for Advanced Colorectal Adenocarcinoma: the Phase II DeFianCe Trial. Clin Cancer Res. 2026 Jul 23. doi: 10.1158/1078-0432.CCR-26-1456. Epub ahead of print. PMID: 42489705.

Tags: Hematology/Oncology, Publications

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