Loss of ATP-Dependent Citrate Lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling

By afschroeder • July 21, 2026

Liu S, Gammon ST, Tan L, Gao Y, Kim K, Elbatreek MH, Arrieta A, Williamson IK, Salazar RL, Pham J, Davidian A, Khanna Neicheril R, Gould BD, Vitrac H, Sadiq A, Dinh AQ, Lien EC, de Luna Vitorino FN, Gongora JM, Martinez SA, Odenkirk MT, Boatman AK, Chappel JR, Czer LSC, Kransdorf EP, Lefer DJ, Hanson BM, Garcia BA, Baker EM, Vander Heiden MG, Lorenzi PL, Taegtmeyer H, Piwnica-Worms D, Martin JF, Karlstaedt A. Loss of ATP-Dependent Citrate Lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling. Circulation. 2026 Jul 21;154(3):223-239. doi: 10.1161/CIRCULATIONAHA.125.076453. Epub 2026 Jul 20. PMID: 42475434.

Tags: ATP-dependent citrate lyase, cardio-oncology, Cardiology/Epi, Cedars Sinai DoM, Metabolism, Publications, systems biology

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