Avutometinib, Abemaciclib, and Fulvestrant in Patients with HR+/HER2- Metastatic Breast Cancer Previously Treated with CDK4/6 Inhibitor: A Single-Arm Phase I Trial

By afschroeder • July 14, 2026

Waks AG, Segui E, Li T, Lipsyc-Sharf M, Kallfelz E, DiLullo M, Patel A, Rahman T, Junkins K, Rahee H, Frey AM, Kelly E, Stalteri M, Wrabel E, Williams A, Parsons H, Poorvu PD, Partridge A, Abravanel DL, Poorvu N, LeStage B, Sicinski P, Tolaney SM, Wagle N, Tayob N, Shapiro GI. Avutometinib, Abemaciclib, and Fulvestrant in Patients with HR+/HER2- Metastatic Breast Cancer Previously Treated with CDK4/6 Inhibitor: A Single-Arm Phase I Trial. Clin Cancer Res. 2026 Jul 13. doi: 10.1158/1078-0432.CCR-26-0721. Epub ahead of print. PMID: 42440363.

Tags: Hematology/Oncology, Publications

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