Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

By afschroeder • July 2, 2026

Mykkänen AJH, Hirvensalo P, Klein K, Kaminska D, Grube M, Tapaninen T, Kiiski JI, Neuvonen M, Männistö VT, Pihlajamäki J, Tzvetkov M, Schwab M, Tornio A, Backman JT, Niemi M. Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure. Clin Pharmacol Ther. 2026 Jul 1. doi: 10.1002/cpt.70376. Epub ahead of print. PMID: 42387303.

Tags: Digestive Diseases, Publications

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