Integrated single-cell transcriptomic analysis identifies PF4 + /PPBP + megakaryocyte-like granulocytes associated with immune dysregulation in autoimmune diseases

By afschroeder • May 26, 2026

Chen S, Fan Y, Su M, Lin Y, Zheng S, Zhou Z, Zhang W, Lin J, Hu S, Matucci-Cerinic M, Furst DE, Zhang G, Wang Y. Integrated single-cell transcriptomic analysis identifies PF4⁺/PPBP⁺ megakaryocyte-like granulocytes associated with immune dysregulation in autoimmune diseases. Biochem Biophys Rep. 2026 May 10;46:102615. doi: 10.1016/j.bbrep.2026.102615. PMID: 42180183; PMCID: PMC13191102.

Tags: autoimmune disease, Cell communication, Low-density granulocytes, megakaryocytes, NET formation, Publications, Rheumatology

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