Maternal hyperglycemia disrupts cardiomyocyte maturation via aberrant nucleotide metabolism and suppression of AMPK signaling

By afschroeder • May 7, 2026

Nakano H, Kawahira N, Vesprey A, Nakano A. Maternal hyperglycemia disrupts cardiomyocyte maturation via aberrant nucleotide metabolism and suppression of AMPK signaling. Cell Rep. 2026 May 4;45(5):117321. doi: 10.1016/j.celrep.2026.117321. Epub ahead of print. PMID: 42090289.

Tags: AMPK signaling, Cardiac maturation, cardiogenesis, Cardiology/Epi, CP: Metabolism, CP: molecular biology, diabetic embryopathy, hiPSC-derived cardiomyocytes, Metabolism, mitochondrial dynamics, nucleotide metabolism, Publications

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