Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer

By afschroeder • April 16, 2026

Su Y, Liu C, Lu X, Chuang HY, Li G, Shao S, Kong Y, Lee JW, Ng RH, Wong S, Robert L, Warden C, Liu V, Chen J, Wang Z, Qin G, Tang Y, Cheng H, Ng AHC, Chen D, Peng S, Xue M, Johnson D, Xu Y, Wang J, Wu X, Shmulevich I, Shi Q, Levine R, Ribas A, Baltimore D, Guo J, Heath JR, Wei W. Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer. Nat Commun. 2026 Apr 15;17(1):3228. doi: 10.1038/s41467-026-71349-4. PMID: 41986344.

Tags: Hematology/Oncology, Publications

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