A microbiome quantitative trait locus in SLC39A8 modulates disease severity in synucleinopathy-induced models of Parkinson’s disease

By afschroeder • April 10, 2026

Yang JC, Situ J, Troutman R, Zhu R, Black M, Buri H, Gutta A, Tian F, Kang A, Aja E, Zeng A, Lai RW, Tan J, Liang F, Brahim C, Murphy G, Ahdoot A, Peng C, Jacobs JP. A microbiome quantitative trait locus in SLC39A8 modulates disease severity in synucleinopathy-induced models of Parkinson's disease. Hum Mol Genet. 2026 Mar 23;35(6):ddag024. doi: 10.1093/hmg/ddag024. PMID: 41955304.

Tags: Cardiology/Epi, Digestive Diseases, Gene-microbiome interaction, Gut microbiome, mbQTL, microbiome quantitative trait locus, Parkinson’s disease; SLC39A8, Publications, Veterans Administration

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