A randomized controlled trial of pulsed field ablation vs antiarrhythmic therapy as a first-line treatment for persistent atrial fibrillation: The AVANT GUARD trial rationale and design

By afschroeder • March 31, 2026

Wazni OM, Chun KJ, Amin A, Anic A, Ajijola OA, Gibson DN, Mansour M, Makati K, Chrispin J, Duytschaever M, Nair DG, Piccini JP, Natale A, Raciti G, Wehrenberg S, McCammon S, Albrecht EM, Garlitski A, Sutton BS, Andrade JG; AVANT GUARD Investigators. A randomized controlled trial of pulsed field ablation vs antiarrhythmic therapy as a first-line treatment for persistent atrial fibrillation: The AVANT GUARD trial rationale and design. Heart Rhythm O2. 2025 Dec 23;7(3):561-574. doi: 10.1016/j.hroo.2025.12.011. PMID: 41908201; PMCID: PMC13031045.

Tags: antiarrhythmic drugs, Cardiology/Epi, catheter ablation, First-line therapy, persistent atrial fibrillation, Publications, pulsed field ablation, Randomized Controlled Trial

Cardiac Myxoma With Atypical Presentation Leading to Delayed Diagnosis: A Case Report

Alishala M, Trinh T, Lee JS. Cardiac Myxoma With Atypical Presentation Leading to Delayed Diagnosis: A Case Report. Cureus. 2026 Feb 26;18(2):e104308. doi: 10.7759/cureus.104308. PMID:[...]

Effect of APOC3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study

Marston NA, Bergmark BA, Prohaska TA, Moura FA, Zimerman A, Alexander VJ, Kang YM, Weinland J, Ran X, Murphy SA, Zhang S, Li D, Banach[...]

Cardiogenic Shock From Chronic Immune Checkpoint Inhibitor Associated Myocarditis Causing Predominant Right Ventricular Failure

Sekhon H, Rajendran PS, Hampilos K, Raddatz MA, Lilley CM, Zinoviev RI, Tai W, Stein-Merlob AF, Fishbein GA, Yang EH. Cardiogenic Shock From Chronic Immune[...]