Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease

By afschroeder • February 9, 2026

Ma J, Lai CQ, Li XS, Wang M, Wang Z, Yao J, Guo X, Taylor KD, Lee S, Tracy RP, Peter D, Liu Y, Rotter JI, Rich SS, Budoff M, Tang W, DiDonato JA, Brody JA, Lemaitre RN, Fretts A, Sotoodehnia N, Psaty BM, Ordovás JM, Siscovick DS, Hazen SL, Mozaffarian D. Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease. Clin Epigenetics. 2026 Feb 9. doi: 10.1186/s13148-026-02060-w. Epub ahead of print. PMID: 41656272.

Tags: Cardiology/Epi, Harbor UCLA, Publications

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