1. < Cedars Sinai DoM

Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis

By afschroeder • February 6, 2026

Kaundal U, Tsou PS, Sahu M, Huang M, Boyden SE, Woodford CM, Shriner D, Stenson E, Safran SA, Zhou Y, Talley TA, Gudapati K, Zhang X, Kunishita Y, Wang J, Shah AA, Mayes MD, Doumatey AP, Bentley AR, Domsic R, Medsger TA Jr, Ramos PS, Silver RM, Steen V, Varga J, Hsu V, Saketkoo LA, Schiopu E, Gordon JK, Criswell LA, Gladue H, Derk C, Bernstein EJ, Bridges SL Jr, Shanmugam V, Chung L, Kafaja S, Jan R, Trojanowski M, Goldberg A, Korman BD, Mullikin J, Thomas JW, Dell'Orso S, Randazzo D, Adeyemo A, Remmers EF, Schwartzberg PL, Aksentijevich I, Rotimi C, Wigley FM, Wang RA, Boin F, Khanna D, Lafyatis R, Kastner DL, Gourh P. Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis. Ann Rheum Dis. 2026 Feb 4:S0003-4967(25)04609-6. doi: 10.1016/j.ard.2025.12.015. Epub ahead of print. PMID: 41644364.

Tags: Cedars Sinai DoM, Publications, Rheumatology

Related Posts

Long-term outcomes of patients receiving Dialysis and undergoing Transcatheter aortic valve replacement with contemporary balloon-expandable valves

Shitan H, Patel V, Suruga K, Guo Y, Ng D, Cole B, Gupta A, Chakravarty T, Cheng W, Okada Y, Jilaihawi H, Nakamura M, Makkar[...]

Real-World Outcomes of Dedicated Leaflet Modification for Bioprosthetic Valve-In-Valve TAVR: A 150-Patient Commercial Experience

Makkar RR, Gupta A, Inglessis I, Stinis CT, Yadav PK, Thourani VH, Chetcuti SJ, Summers M, Patel V, Chehab BM, Patel A, Tang GHL, Khera[...]

Racial and Sex Differences in Postoperative Mortality Between Patients With Versus Without Dementia

Yoshida R, Nuckols TK, Norris K, Maggard-Gibbons M, de Virgilio C, Klomhaus A, Li R, Li YJ, Tsugawa Y, Gotanda H. Racial and Sex Differences[...]