Practice changing RCT design and rationale: Abbreviated MRI plus AFP vs. ultrasound plus AFP for HCC surveillance in cirrhosis (PREMIUM study)

By afschroeder • February 3, 2026

Ioannou GN, Taddei TH, Planeta BM, Huang GD, Weiss NS, Morgan TR, Dominitz JA, Abou-Alfa GK, Bashir MR, Beheshti MV, Singal AG, Moylan CA, Boland RJ, Buchwalder LF, Mehta RL, Hoisington KS, Do NV, Rogal SS, Kaplan DE, Benhammou JN, Su GL, McDonald LM, Dani G, Dunn DP, Chang ST, Onyiuke IY, Sharma A, Kyriakides TC; PREMIUM Study Group. Practice changing RCT design and rationale: Abbreviated MRI plus AFP vs. ultrasound plus AFP for HCC surveillance in cirrhosis (PREMIUM study). JHEP Rep. 2025 Nov 6;8(2):101666. doi: 10.1016/j.jhepr.2025.101666. PMID: 41624484; PMCID: PMC12857331.

Tags: abbreviated MRI, alpha fetoprotein, Cirrhosis, Digestive Diseases, Hepatocellular carcinoma, liver cancer screening, Publications, ultrasound, Veterans Administration

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