Testosterone deficiency synergistically exacerbates fructose-induced hepatic steatosis through gut microbiota and pyruvate in mice

By afschroeder • January 7, 2026

Takahashi H, Harada N, Hayamizu Y, Dungubat E, Nakazawa M, Kitakaze T, Sugimoto K, Inui H, Yoshihara E, Takahashi Y, Yamaji R. Testosterone deficiency synergistically exacerbates fructose-induced hepatic steatosis through gut microbiota and pyruvate in mice. Am J Physiol Endocrinol Metab. 2026 Jan 6. doi: 10.1152/ajpendo.00518.2025. Epub ahead of print. PMID: 41494643.

Tags: Androgen, castration, Endocrinology, Fatty Liver, Gut microbiome, Harbor UCLA, Publications, pyruvate

Investigating Endogenous Hypercortisolism Prevalence in a U.S. Population With Resistant Hypertension: MOMENTUM Rationale and Design

Plutzky J, Taub PR, Bhatt DL, Al Dhaybi O, Aroda VR, Basile JN, Bloch MJ, Budoff M, Busch RS, Buse JB, Cheung D, Christofides EA,[...]

Mitochondrial oxidants promote platelet activation and thrombotic susceptibility in prediabetes

Ahmed A, Yadav P, Jensen M, Geasland K, Swamy J, Spitz DR, Abel ED, Jalal D, Dayal S. Mitochondrial oxidants promote platelet activation and thrombotic[...]

Lipidomic profiles associated with treatment related hepatotoxicity in children with acute lymphoblastic leukemia

Mason EJ, Schraw JM, Woodhouse JP, Gramatges MM, Williams KJ, Chen B, Harrell MB, Taylor OA, Scheurer ME, Lupo PJ, Rabin KR, Yi JS, Huynh[...]