Testosterone deficiency synergistically exacerbates fructose-induced hepatic steatosis through gut microbiota and pyruvate in mice

By afschroeder • January 7, 2026

Takahashi H, Harada N, Hayamizu Y, Dungubat E, Nakazawa M, Kitakaze T, Sugimoto K, Inui H, Yoshihara E, Takahashi Y, Yamaji R. Testosterone deficiency synergistically exacerbates fructose-induced hepatic steatosis through gut microbiota and pyruvate in mice. Am J Physiol Endocrinol Metab. 2026 Jan 6. doi: 10.1152/ajpendo.00518.2025. Epub ahead of print. PMID: 41494643.

Tags: Androgen, castration, Endocrinology, Fatty Liver, Gut microbiome, Harbor UCLA, Publications, pyruvate

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