Clonal hematopoiesis activates procalcific pathways in macrophages and promotes aortic valve stenosis

By sjmartinez • January 3, 2026

Abplanalp WT, Raddatz MA, Schuhmacher B, Mas-Peiro S, Zuriaga MA, Matesanz N, Fuster JJ, Pershad Y, Vlasschaert C, Silver AJ, Farber-Eger E, Xu Y, Wells QS, Shahidi D, Fatima S, Yang X, Boruah AA, Ware A, Merten M, von Scheidt M, John D, Shumliakivska M, Muhly-Reinholz M, Vasa-Nicotera M, Guenter S, Savona MR, Lindman BR, Dimmeler S, Bick AG, Zeiher AM. Clonal hematopoiesis activates procalcific pathways in macrophages and promotes aortic valve stenosis. J Clin Invest. 2025 Nov 18;136(1):e171634. doi: 10.1172/JCI171634. PMID: 41252200; PMCID: PMC12721883.

Tags: Aging, Cardiology/Epi, cardiovascular disease, Fellow, Inflammation, monocytes, Publications

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