A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia

By sjmartinez • January 3, 2026

Yang Y, Beigneux AP, Lowe TL, Chen YQ, Xie K, Jung H, Tu Y, Yu RG, Scheithauer JL, Mehta S, Wu J, Alvarez L, Davidson WS, Birrane G, Remaley AT, Sviridov D, Ploug M, Zhen EY, Qian Y, Sloan JH, Siegel RW, Konrad RJ, Fong LG, Young SG. A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia. Proc Natl Acad Sci U S A. 2026 Jan 6;123(1):e2528664123. doi: 10.1073/pnas.2528664123. Epub 2026 Jan 2. PMID: 41481469.

Tags: Cardiology/Epi, DGSOM Student, human Fab bacteriophage, Hypertriglyceridemia, lipoprotein lipase, monoclonal antibody, Post Doc, Publications, triglycerides

Adult Congenital Heart Disease Workforce Challenges in the United States: Current State and Future Needs: Proceedings from the American College of Cardiology (ACC), Adult Congenital Pediatric Cardiology (ACPC) Council Adult Congenital Heart Disease Summit

Zaidi AN, Sachdeva R, Kovacs R, Franklin WJ, Gurvitz M, Ermis P, Awerbach JD, Weissman G, Bradley E, Cox D, Daniels CJ, Gregg D 4th,[...]

Longitudinal Data from the KETO-CTA Study: Plaque Predicts Plaque, ApoB Does Not: JACC Adv. 2025;4(7):101686

Soto-Mota A, Norwitz NG, Manubolu VS, Kinninger A, Wood TR, Earls J, Feldman D, Budoff M. Longitudinal Data from the KETO-CTA Study: Plaque Predicts Plaque,[...]

Primary Cardiac Angiosarcoma Leading to Tamponade and Fatal Right Atrial Rupture

Makaroff KE, Hampilos K, Sayed S, Emert B, Hu X, Nsair A, Kwon M, Middlekauff H. Primary Cardiac Angiosarcoma Leading to Tamponade and Fatal Right[...]