A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia

By sjmartinez • January 3, 2026

Yang Y, Beigneux AP, Lowe TL, Chen YQ, Xie K, Jung H, Tu Y, Yu RG, Scheithauer JL, Mehta S, Wu J, Alvarez L, Davidson WS, Birrane G, Remaley AT, Sviridov D, Ploug M, Zhen EY, Qian Y, Sloan JH, Siegel RW, Konrad RJ, Fong LG, Young SG. A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia. Proc Natl Acad Sci U S A. 2026 Jan 6;123(1):e2528664123. doi: 10.1073/pnas.2528664123. Epub 2026 Jan 2. PMID: 41481469.

Tags: Cardiology/Epi, DGSOM Student, human Fab bacteriophage, Hypertriglyceridemia, lipoprotein lipase, monoclonal antibody, Post Doc, Publications, triglycerides

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