A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia

By sjmartinez • January 3, 2026

Yang Y, Beigneux AP, Lowe TL, Chen YQ, Xie K, Jung H, Tu Y, Yu RG, Scheithauer JL, Mehta S, Wu J, Alvarez L, Davidson WS, Birrane G, Remaley AT, Sviridov D, Ploug M, Zhen EY, Qian Y, Sloan JH, Siegel RW, Konrad RJ, Fong LG, Young SG. A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia. Proc Natl Acad Sci U S A. 2026 Jan 6;123(1):e2528664123. doi: 10.1073/pnas.2528664123. Epub 2026 Jan 2. PMID: 41481469.

Tags: Cardiology/Epi, DGSOM Student, human Fab bacteriophage, Hypertriglyceridemia, lipoprotein lipase, monoclonal antibody, Post Doc, Publications, triglycerides

Reperfusion Strategies for Acute Pulmonary Embolism: Design and Rationale of RECONNECT-PE – a Living Systematic Review and Meta-analysis

Farmakis IT, Binder H, Chopard R, Christodoulou KC, Evrenoglou T, Fengler K, Giri J, Hobohm L, Jaber WA, Klok FA, Kocka V, Kroupa J, Kucher[...]

MoCo + ROVir: Synergy Between Respiratory Motion Compensation and Cardiac Receive Region Focusing for Cardiac MRI

Hu Z, Lee HL, Cao T, Yoshida T, Ma L, Finn JP, Nguyen KL, Christodoulou AG. MoCo + ROVir: Synergy Between Respiratory Motion Compensation and Cardiac Receive[...]

The Cost-Effectiveness Evolution of Cardiovascular Care

Fonarow GC, Navar AM, Yancy CW. The Cost-Effectiveness Evolution of Cardiovascular Care. JAMA Cardiol. 2026 Feb 4. doi: 10.1001/jamacardio.2025.5240. Epub ahead of print. PMID: 41637084.