Large-bore mechanical thrombectomy vs standard of care for acute high-risk pulmonary embolism: rationale and design of the PERSEVERE randomized controlled trial

By sjmartinez • December 27, 2025

Chopard R, Hobohm L, Barco S, Bangalore S, Giri J, Mahfoud F, Moriarty J, Rosenkranz S, Sharp A, Thiele H, Toma C, Tapson VF, Markovitz CD, Rosenberg SP, Konstantinides S, Meneveau N. Large-bore mechanical thrombectomy vs standard of care for acute high-risk pulmonary embolism: rationale and design of the PERSEVERE randomized controlled trial. Am Heart J. 2025 Dec 24:107331. doi: 10.1016/j.ahj.2025.107331. Epub ahead of print. PMID: 41453591.

Tags: Cardiology/Epi, hemodynamic instability, Percutaneous mechanical thrombectomy, Publications, pulmonary embolism, Randomized Controlled Trial

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