Efficacy assessments of EL219, a next-generation polyene antifungal, in immunosuppressed mice infected with drug-sensitive and drug-resistant Aspergillus isolates

By afschroeder • December 6, 2025

Youssef EG, Gebremariam T, Gu Y, Patterson H, Alkhazraji S, Elsayed T, Wiederhold NP, Ibrahim AS. Efficacy assessments of EL219, a next-generation polyene antifungal, in immunosuppressed mice infected with drug-sensitive and drug-resistant Aspergillus isolates. Antimicrob Agents Chemother. 2025 Dec 5:e0140025. doi: 10.1128/aac.01400-25. Epub ahead of print. PMID: 41347521.

Tags: antifungal agents, Aspergillus, EL219, Harbor UCLA, infection model, Infectious Diseases, liposomal amphotericin B, murine, polyene, Post Doc, Publications, SF001

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