Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions

By afschroeder • November 8, 2025

Peng F, Sinjab A, Dai Y, Treekitkarnmongkol W, Yang S, Gomez Bolanos LI, Zhou T, Chen M, Serrano AG, Krishna A, Karimi N, Sharma M, Basi A, Pei G, Liao J, Liu Y, Feng J, Rahal Z, Liu Y, Jiang J, Yu K, Noun T, Liu Y, Khan K, Cho KS, Chen J, Solis LM, Mazzilli S, Dubinett S, Cascone T, Spira AE, Swisher S, Jimbo N, Hayashi T, Kishikawa S, Takamochi K, Itoh T, Yao T, Suzuki K, Kalhor N, Wistuba II, Li M, Moghaddam SJ, Fujimoto J, Burks J, Myers J, Akdemir K, Wang L, Kadara H. Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions. Cancer Cell. 2025 Nov 6:S1535-6108(25)00445-3. doi: 10.1016/j.ccell.2025.10.004. Epub ahead of print. PMID: 41202811.

Tags: alveolar progenitors, epithelial-immune niche, IL-1β, LUAD interception, Lung adenocarcinoma, lung precursor lesions, proinflammatory pathways, Publications, Pulmonary, Critical Care & Sleep Medicine, reactive type II pneumocytes, Spatial transcriptomics, Xenium in situ

Social wellbeing, loneliness, and symptom burden in head and neck cancer survivors: a latent class analysis

Brauer ER, Choi KR, Petersen L, Ganz PA, St John MA, Wong DJ, Martin EJ. Social wellbeing, loneliness, and symptom burden in head and neck[...]

Pulmonary Rehabilitation Prolongs Life…And May Be Dying

Mosher CL, Casaburi R. Pulmonary Rehabilitation Prolongs Life…And May Be Dying. Am J Respir Crit Care Med. 2026 Apr 7:aamag168. doi: 10.1093/ajrccm/aamag168. Epub ahead of[...]

Plasma metabolomic profiles associated with cardiovascular disease in type 2 diabetes from the Trans-Omics for Precision Medicine (TOPMed) program

Zhang Y, Nguyen NQH, Hanson PA, Sevilla-Gonzalez M, Haessler J, Sarnowski C, Yao J, Yu B, Jamshidi A, Boerwinkle E, Brown MR, Chen ZZ, Ida[...]