Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions

By afschroeder • November 8, 2025

Peng F, Sinjab A, Dai Y, Treekitkarnmongkol W, Yang S, Gomez Bolanos LI, Zhou T, Chen M, Serrano AG, Krishna A, Karimi N, Sharma M, Basi A, Pei G, Liao J, Liu Y, Feng J, Rahal Z, Liu Y, Jiang J, Yu K, Noun T, Liu Y, Khan K, Cho KS, Chen J, Solis LM, Mazzilli S, Dubinett S, Cascone T, Spira AE, Swisher S, Jimbo N, Hayashi T, Kishikawa S, Takamochi K, Itoh T, Yao T, Suzuki K, Kalhor N, Wistuba II, Li M, Moghaddam SJ, Fujimoto J, Burks J, Myers J, Akdemir K, Wang L, Kadara H. Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions. Cancer Cell. 2025 Nov 6:S1535-6108(25)00445-3. doi: 10.1016/j.ccell.2025.10.004. Epub ahead of print. PMID: 41202811.

Tags: alveolar progenitors, epithelial-immune niche, IL-1β, LUAD interception, Lung adenocarcinoma, lung precursor lesions, proinflammatory pathways, Publications, Pulmonary, Critical Care & Sleep Medicine, reactive type II pneumocytes, Spatial transcriptomics, Xenium in situ

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