Collagen-binding IL-12-armoured STEAP1 CAR-T cells reduce toxicity and treat prostate cancer in mouse models

By afschroeder • October 23, 2025

Sasaki K, Bhatia V, Asano Y, Bakhtiari J, Kaur P, Wang C, Matsuo T, Dubois O, Chiu PC, Gun D, Singh C, Panagi I, Noblecourt L, Nikolaidi M, Chong T, Javier G, Priceman SJ, Chapuis AG, Lee JK, Ishihara J. Collagen-binding IL-12-armoured STEAP1 CAR-T cells reduce toxicity and treat prostate cancer in mouse models. Nat Biomed Eng. 2025 Oct 23. doi: 10.1038/s41551-025-01508-3. Epub ahead of print. PMID: 41125870.

Tags: Hematology/Oncology, Publications

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