Probing DNA damage in Rett syndrome neurons uncovers a role for MECP2 regulation of PARP1

By afschroeder • September 27, 2025

Morales A, Korsakova E, Mansooralavi N, Ravikumar A, Rivas G, Soliman P, Rodriguez L, McDaniel T, Lund A, Cooper B, Bhaduri A, Lowry WE. Probing DNA damage in Rett syndrome neurons uncovers a role for MECP2 regulation of PARP1. Stem Cell Reports. 2025 Sep 25:102645. doi: 10.1016/j.stemcr.2025.102645. Epub ahead of print. PMID: 41005313.

Tags: CDKL5, Dermatology, DNA repair, human neurons, intellectual disability, MECP2, PARP1, Publications, Rett syndrome, senescence

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