Probing DNA damage in Rett syndrome neurons uncovers a role for MECP2 regulation of PARP1

By afschroeder • September 27, 2025

Morales A, Korsakova E, Mansooralavi N, Ravikumar A, Rivas G, Soliman P, Rodriguez L, McDaniel T, Lund A, Cooper B, Bhaduri A, Lowry WE. Probing DNA damage in Rett syndrome neurons uncovers a role for MECP2 regulation of PARP1. Stem Cell Reports. 2025 Sep 25:102645. doi: 10.1016/j.stemcr.2025.102645. Epub ahead of print. PMID: 41005313.

Tags: CDKL5, Dermatology, DNA repair, human neurons, intellectual disability, MECP2, PARP1, Publications, Rett syndrome, senescence

US expert opinions on the treatment of bullous pemphigoid based on guidelines from the European Academy of Dermatology and Venereology

Kasperkiewicz M, Thapa M, Adotama P, Tomayko MM, Culton DA. US expert opinions on the treatment of bullous pemphigoid based on guidelines from the European[...]

Single-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus

Jiang R, Bogle R, Xing X, Kirma J, Fox J, Harms PW, Do T, Billi AC, Kahlenberg JM, Modlin RL, Teles R, West J, Mangold[...]

Concordance Between Patient- and Physician-Reported Improvement With Dupilumab in Atopic Dermatitis

Conde G, Carmenate Y, Bello G, Armstrong AW. Concordance Between Patient- and Physician-Reported Improvement With Dupilumab in Atopic Dermatitis. J Dermatol. 2026 Mar 13. doi:[...]