Lysosomal LRRC8 complex impacts lysosomal pH, morphology, and systemic glucose metabolism

Kumar A, Zhao Y, Xie L, Chadda R, Tranter JD, Mikami RT, Abraham N, Hong J, Feng E, Rawnsley DR, Liu H, Henry KM, Meyer G, Hu M, Xu H, Hinton A Jr, Grueter CE, Abel ED, Norris AW, Diwan A, Sah R. Lysosomal LRRC8 complex impacts lysosomal pH, morphology, and systemic glucose metabolism. Sci Adv. 2025 Sep 26;11(39):eadt6366. doi: 10.1126/sciadv.adt6366. Epub 2025 Sep 26. PMID: 41004571; PMCID: PMC12466849.


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