Methadone Blockade of Inward Rectifier Potassium Current Promotes Both Early and Delayed Repolarization Arrhythmias: Mechanistic Insights From Computational Modeling

By afschroeder • September 26, 2025

Zhang Z, Green JT, Haigney MC, Walker P, Shivkumar K, Garfinkel A, Qu Z. Methadone Blockade of Inward Rectifier Potassium Current Promotes Both Early and Delayed Repolarization Arrhythmias: Mechanistic Insights From Computational Modeling. J Am Heart Assoc. 2025 Sep 25:e042201. doi: 10.1161/JAHA.125.042201. Epub ahead of print. PMID: 40996098.

Tags: Brugada syndrome, Cardiology/Epi, early replarization, long QT syndrome, methadone, phase 2 reentry, Publications, tissue‐scale phenomenon

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