Methadone Blockade of Inward Rectifier Potassium Current Promotes Both Early and Delayed Repolarization Arrhythmias: Mechanistic Insights From Computational Modeling

By afschroeder • September 26, 2025

Zhang Z, Green JT, Haigney MC, Walker P, Shivkumar K, Garfinkel A, Qu Z. Methadone Blockade of Inward Rectifier Potassium Current Promotes Both Early and Delayed Repolarization Arrhythmias: Mechanistic Insights From Computational Modeling. J Am Heart Assoc. 2025 Sep 25:e042201. doi: 10.1161/JAHA.125.042201. Epub ahead of print. PMID: 40996098.

Tags: Brugada syndrome, Cardiology/Epi, early replarization, long QT syndrome, methadone, phase 2 reentry, Publications, tissue‐scale phenomenon

Long-Term Survival in Liver Transplant Patients With Coronary Artery Disease: A Multi-Institutional Study

Wray CL, Scovotti JC, Tobis J, Honda HM, Planinsic R, Walia A, Findlay J, Wagener G, Cywinski JB, Olmos A, Markovic D, Hughes C, Humar[...]

Psychological and emotional drivers of atherosclerotic cardiovascular disease: Screening the brain to protect the heart

Atmani K, Vaseghi M. Psychological and emotional drivers of atherosclerotic cardiovascular disease: Screening the brain to protect the heart. Trends Cardiovasc Med. 2025 Nov 4:S1050-1738(25)00145-8.[...]

Cardiac resynchronisation therapy among adults with a systemic right ventricle: a multicentre experience

Fusco F, Scognamiglio G, Dellborg M, Dehghani P, Jameson SM, Kay WA, Cramer JW, Vonder Muhll I, Krieger EV, Rodriguez FH, Burchill LJ, Nicolarsen J,[...]