Two randomized controlled Phase 2 studies of the oral neutrophil elastase inhibitor alvelestat in alpha-1 antitrypsin deficiency

By afschroeder • September 19, 2025

Wells JM, Titlestad IL, Tanash H, Turner AM, Chapman KR, Hatipoğlu UŞ, Goldklang MP, D'Armiento JM, Pirozzi CS, Drummond MB, Barjaktarevic IZ, Chatila WM, Devine MS, Strange C, Sandhaus RA, Parkin JM, Westfall E, Lin VY, Parks R, Kuo HC, Ekue A, Moffitt KL, Inshaw J, Aban I, Dransfield MT, Stockley RA. Two randomized controlled Phase 2 studies of the oral neutrophil elastase inhibitor alvelestat in alpha-1 antitrypsin deficiency. Eur Respir J. 2025 Sep 18:2501019. doi: 10.1183/13993003.01019-2025. Epub ahead of print. PMID: 40967767.

Tags: Publications, Pulmonary, Critical Care & Sleep Medicine

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