Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction

By afschroeder • September 7, 2025

Zhao X, Liu B, William WN, Tsanov KM, Ho YJ, Barriga FM, Lim RJ, Trifas M, Khandekar A, Du Y, Lowe SW, Dubinett SM, Davoli T, Lippman SM. Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction. J Thorac Oncol. 2025 Sep;20(9):1177-1236. doi: 10.1016/j.jtho.2024.12.020. Epub 2024 Dec 24. PMID: 39725169.

Tags: chemokines, chromosome 9p, genomic copy number alterations, immunotherapy, interferons, Publications, Pulmonary, Critical Care & Sleep Medicine, TP53, vaccines

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