Randomized Phase 2 Trial of an Extended and Flexible Dosing Schedule of 177Lu-PSMA Molecular Radiotherapy in Patients with Metastatic Castration-Resistant Prostate Cancer (FLEX-MRT): Study Protocol

By afschroeder • August 29, 2025

Holzgreve A, Delker A, Ells Z, Brosch-Lenz J, Unterrainer LM, Nikitas J, Zhu S, Contreras MM, Alam H, Nabong RM, Lira S, Vasilyev A, Chen L, Grogan T, Elashoff D, Meyer CA, Dahlbom M, Czernin J, Calais J. Randomized Phase 2 Trial of an Extended and Flexible Dosing Schedule of ¹⁷⁷Lu-PSMA Molecular Radiotherapy in Patients with Metastatic Castration-Resistant Prostate Cancer (FLEX-MRT): Study Protocol. J Nucl Med. 2025 Aug 28:jnumed.125.269495. doi: 10.2967/jnumed.125.269495. Epub ahead of print. PMID: 40876952.

Tags: [177Lu]Lu-PSMA-617, DOM STAT, General Internal Medicine, mCRPC, metastatic castration-resistant prostate cancer, Primary Care, prostate-specific membrane antigen, PSMA, Publications, radiopharmaceutical therapy, RPT, SPECT/CT, therapy response assessment, treatment holidays

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