FXR adapts hepatic mitochondrial function to increased substrate oxidation in patients with obesity

By afschroeder • August 14, 2025

Panzitt K, Jungwirth E, Vosko LE, Madreiter-Sokolowski CT, Madl T, Tawfik I, Habisch H, Krstic J, Prokesch A, Karitnig R, Sucher R, Erdogan CY, Vallim TA, Trauner M, Fickert P, Al-Dury S, Molinaro A, Moore DD, Thallinger GG, Marschall HU, Wagner M. FXR adapts hepatic mitochondrial function to increased substrate oxidation in patients with obesity. Sci Transl Med. 2025 Aug 13;17(811):eadn4558. doi: 10.1126/scitranslmed.adn4558. Epub 2025 Aug 13. PMID: 40802742.

Tags: Cardiology/Epi, Publications

Related Posts

Intensive Versus Standard Blood Pressure Control After Endovascular Thrombectomy in Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials

Hashmi TM, Ahmed M, Ashraf H, Shakir M, Bhatti IA, Ahmed F, Alareed A, Hasan A, Ahmed R, Rafiq S, Aized MT, Fonarow GC, Hassan[...]

p21+TREM2+ senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease

Salladay-Perez IA, Avila I, Estrada L, Alexandru AC, Ponce C, Dhingra A, Torres G, Deng CY, Hegde R, Gensheimer J, Kale A, Heckenbach I, Hui[...]

InChagas: Feasibility Study of a Tele-Education Strategy to Promote Early Identification and Care of People Living with Chagas Cardiomyopathy in an Endemic Community in Argentina

Gulayin PE, Gimenez C, Chirino D, Nascimento B, Salvá L, Cavallo AS, Gutierrez L, Blanco L, Flores LPC, Espina E, Shakil SS, Vervoort D, Davis[...]