Design and rationale of a randomized clinical trial assessing the effect of inclisiran on atherosclerotic plaque in individuals without previous cardiovascular event and without flow- limiting lesions identified in an in-hospital screening – The VICTORION-PLAQUE primary prevention trial

By afschroeder • August 7, 2025

Revaiah PC, Serruys PW, Onuma Y, Andreini D, Budoff MJ, Sharif F, Chernofsky A, Vikarunnessa S, Wiethoff AJ, Yates D, Achouba A. Design and rationale of a randomized clinical trial assessing the effect of inclisiran on atherosclerotic plaque in individuals without previous cardiovascular event and without flow- limiting lesions identified in an in-hospital screening - The VICTORION-PLAQUE primary prevention trial. Am Heart J. 2025 Aug 4:S0002-8703(25)00291-1. doi: 10.1016/j.ahj.2025.08.001. Epub ahead of print. PMID: 40769373.

Tags: Cardiology/Epi, CCTA derived Fractional Flow Reserve (FFR(CT)), coronary computed tomography angiography (CCTA), CT-adapted Leaman score, Harbor UCLA, Inclisiran, Low density Lipoprotein Cholesterol (LDL-C), non-obstructive coronary artery disease (NOCAD), Publications, total atheroma volume (TAV)

Comparative physiology and biomimetics in metabolic and environmental health: what can we learn from extreme animal phenotypes?

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The Role of Coronary Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction

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Automated evaluation for pericardial effusion and cardiac tamponade with echocardiographic artificial intelligence

Chiu IM, Sahashi Y, Vukadinovic M, Cheng PP, Cheng S, Ouyang D. Automated evaluation for pericardial effusion and cardiac tamponade with echocardiographic artificial intelligence. Eur[...]