Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial

By afschroeder • July 31, 2025

Parks KR, Moodie Z, Allen MA, Yen C, Furch BD, MacPhee KJ, Ozorowski G, Heptinstall J, Hahn WO, Zheng Z, Lu H, Grant S, Domin E, Duff MO, Seese A, Marini-Macouzet C, Ballweber-Fleming L, Lee WH, Cottrell CA, Liguori A, Georgeson E, Alavi N, Kubitz M, Phelps N, Seaton KE, Cohen KW, Anderson MA, Mondal K, Laufer DS, Kublin JG, Ward AB, Hyrien O, De Rosa SC, Himansu S, Leav B, Reuter C, Tomaras GD, Montefiori D, Walsh SR, Frank I, Sobieszczyk ME, Goepfert PA, Stephenson KE, Baden LR, Van Tieu H, Keefer MC, Clark J, Riddler SA, Schief WR, McElrath MJ. Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial. Sci Transl Med. 2025 Jul 30;17(809):eady6831. doi: 10.1126/scitranslmed.ady6831. Epub 2025 Jul 30. PMID: 40737434.

Tags: Infectious Diseases, Publications

In Silico Design of a Multiepitope Vaccine Against Intestinal Pathogenic Escherichia coli Based on the 2011 German O104:H4 Outbreak Strain Using Reverse Vaccinology and an Immunoinformatic Approach

Youssef EG, Elnesr K, Hanora A. In Silico Design of a Multiepitope Vaccine Against Intestinal Pathogenic Escherichia coli Based on the 2011 German O104:H4 Outbreak Strain Using[...]

Cabotegravir pharmacokinetics in Asians with and without HIV

Han K, Abulfathi AA, Mehta RS, Nand RA, Marzinke MA, Landovitz RJ, D'Amico RD, Rinehart AR, Spreen WR, Ford SL. Cabotegravir pharmacokinetics in Asians with[...]

Depression improves the predictive accuracy of the VACS Index 2.0 for all-cause mortality among sexual minority men living with HIV in the Multicenter AIDS Cohort Study

Qian Y, Comulada WS, Hidalgo MA, Lee SJ, Friedman MR, Palella FJ, Plankey MW, D'Souza G, Detels R, Mimiaga MJ. Depression improves the predictive accuracy[...]