The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis

By afschroeder • July 8, 2025

Chatterjee P, Canale V, King SJ, Shawki A, Lei H, Santos AN, Haddad M, Gries C, McGovern DPB, Borneman J, McCole DF. The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis. Gut Microbes. 2025 Dec;17(1):2526136. doi: 10.1080/19490976.2025.2526136. Epub 2025 Jul 7. PMID: 40624731.

Tags: AIEC, Cedars Sinai DoM, Digestive Diseases, gut barrier, IBD, JAK-STAT, LF82, Publications, tofacitinib

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