Comorbidities Are Associated With Unfavorable Outcome in Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorders and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: Exploratory Study From the CROCTINO Cohort

By afschroeder • June 10, 2025

Samadzadeh S, Oertel FC, Salih H, Lin TY, Motamedi S, Chien C, Cook LJ, Lana-Peixoto MA, Fontenelle MA, Kim HJ, Hyun JW, Jung SK, Palace J, Roca-Fernandez A, Leite MI, Sharma SM, Ashtari F, Kafieh R, Dehghani A, Pourazizi M, Pandit L, Dcunha A, Aktas O, Ringelstein M, Albrecht P, May EF, Tongco C, Leocani L, Pisa M, Radaelli M, Sánchez-Dalmau B, Martinez-Lapiscina EH, Stiebel-Kalish H, Hellmann MA, Lotan I, Siritho S, de Seze J, Senger T, Havla J, Marignier R, Tilikete CF, Cobo-Calvo A, Bichuetti D, Tavares IM, Soelberg K, Altintas A, Yildirim R, Tanriverdi U, Jacob A, Huda S, Rimler Z, Reid A, Mao-Draayer Y, Villoslada P, de Castillo IS, Green A, Petzold A, Yeaman MR, Smith TJ, Brandt AU, Zimmermann HG, Paul F, Asgari N; Guthy Jackson Charitable Foundation – International Clinical Consortium and CROCTINO Collaborators. Comorbidities Are Associated With Unfavorable Outcome in Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorders and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: Exploratory Study From the CROCTINO Cohort. Eur J Neurol. 2025 Jun;32(6):e70214. doi: 10.1111/ene.70214. PMID: 40485599.

Tags: anti‐aquaporin‐4 (AQP4), anti‐myelin oligodendrocyte glycoprotein antibody‐associated disease, comorbidity, double‐seronegative NMOSD, Harbor UCLA, Infectious Diseases, Neuromyelitis optica spectrum disorder, Optical coherence tomography, Publications

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Choo S. Pager. JAMA. 2026 Jun 17. doi: 10.1001/jama.2026.6134. Epub ahead of print. PMID: 42307957.

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