Intentional heterogeneity in autologous cell-based gene therapies: strategic considerations for first-in-human trials

By afschroeder • June 8, 2025

Cabanski CR, Yang E, Stewart MD, Allen JD, Connolly JE, Dugan U, Greenberg PD, Mackall CL, June CH, Marson A, Maus MV, Ribas A. Intentional heterogeneity in autologous cell-based gene therapies: strategic considerations for first-in-human trials. J Immunother Cancer. 2025 Jun 5;13(6):e011301. doi: 10.1136/jitc-2024-011301. PMID: 40480658; PMCID: PMC12142127.

Tags: Adoptive cell therapy - ACT, Chimeric antigen receptor - CAR, Gene therapy, Hematology/Oncology, Publications, Solid tumor, T cell Receptor - TCR

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