Nrf2- and p53-inducible REDD2/DDiT4L/Rtp801L confers pancreatic β-cell dysfunction, leading to glucose intolerance in high-fat diet-fed mice

By sjmartinez • May 24, 2025

Yamada Y, Urakawa N, Tamiya H, Sakamoto S, Takahashi H, Harada N, Kitakaze T, Izawa T, Matsumua S, Yoshihara E, Inui H, Mashimo T, Yamaji R. Nrf2- and p53-inducible REDD2/DDiT4L/Rtp801L confers pancreatic β-cell dysfunction, leading to glucose intolerance in high-fat diet-fed mice. J Biol Chem. 2025 May 21:110271. doi: 10.1016/j.jbc.2025.110271. Epub ahead of print. PMID: 40409543.

Tags: DDiT4L, DNA damage-inducible transcript 4-like, Endocrinology, gene knockout, Harbor UCLA, Nrf2, nuclear factor erythroid 2 related factor 2, oxidative stress p53, pancreatic β-cell, Publications, REDD2, streptozotocin, Stress response, STZ, the regulated in development and DNA damage response 2, Type 2 diabetes

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