Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson’s disease

By sjmartinez • April 26, 2025

Gregori M, Pereira GJS, Allen R, West N, Chau KY, Cai X, Bostock MP, Bolsover SR, Keller M, Lee CY, Lei SH, Harvey K, Bracher F, Grimm C, Hasan G, Gegg ME, Schapira AHV, Sweeney ST, Patel S. Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease. J Cell Biol. 2025 Jun 2;224(6):e202412055. doi: 10.1083/jcb.202412055. Epub 2025 Apr 25. PMID: 40279672; PMCID: PMC12029513.

Tags: Cardiology/Epi, Publications

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