Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson’s disease

By sjmartinez • April 26, 2025

Gregori M, Pereira GJS, Allen R, West N, Chau KY, Cai X, Bostock MP, Bolsover SR, Keller M, Lee CY, Lei SH, Harvey K, Bracher F, Grimm C, Hasan G, Gegg ME, Schapira AHV, Sweeney ST, Patel S. Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease. J Cell Biol. 2025 Jun 2;224(6):e202412055. doi: 10.1083/jcb.202412055. Epub 2025 Apr 25. PMID: 40279672; PMCID: PMC12029513.

Tags: Cardiology/Epi, Publications

Related Posts

Cardiovascular Imaging Considerations for Masters-Aged Athletes

Phelan DM, Claessen G, Eijsvogels TMH, Churchill TW, Dineen EH, Gati S, Guseh JS 2nd, Hsu JJ, Shah AB, Sperry BW, Wasfy MM, La Gerche[...]

Prognostic Value of AI-Based Quantitative Coronary CTA vs Human Reader-Based Visual Assessment: Results From the CONFIRM2 Registry

van Rosendael A, Nakanishi R, Bax JJ, Pontone G, Mushtaq S, Buechel RR, Gräni C, Feuchtner G, Lacaita PG, Patel AR, Singulane CC, Choi AD,[...]

Obesity mortality on the rise: A 54-year US perspective

Aamir J, Afridi MK, Sajid M, Khan TM, Qureshi S, Ahmed R, Fonarow GC, Minhas AMK, Waqas SA. Obesity mortality on the rise: A 54-year[...]