Noninvasive Assessment of β-Secretase Activity Through Click Chemistry-Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer’s Disease

By sjmartinez • April 18, 2025

Kim H, Lee J, Qian A, Ji YR, Zhang R, Hu Q, Williams CK, Chuang HY, Smalley MD, Xu Y, Gao L, Mayo MC, Zhang T, Posadas EM, Tan ZS, Vinters HV, Vossel K, Magaki S, Zhu Y, Tseng HR. Noninvasive Assessment of β-Secretase Activity Through Click Chemistry-Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease. Adv Sci (Weinh). 2025 Apr 17:e2415289. doi: 10.1002/advs.202415289. Epub ahead of print. PMID: 40245252.

Tags: Alzheimer’s disease, Cedars Sinai DoM, General Internal Medicine, Hematology/Oncology, Liquid biopsy, neurodegenerative disease, neuronal extracellular vesicle, Publications, β‐secretase

A phase 1 safety and feasibility trial of a ketogenic diet plus standard of care for patients with recently diagnosed glioblastoma

Amaral LJ, Gresham G, Kim S, Tighiouart M, Nelson TA, Welborn A, Lockshon L, Noorvash B, Rudnick JD, Irwin SA, Freedland SJ, Hu J. A[...]

Impact and management of warm autoimmune haemolytic anaemia associated with systemic lupus erythematosus

Pons-Estel GJ, Mosca M, Wallace DJ, Zazzetti F, Leon A, Noël W, Pierce A, Ebrahim T, Murakhovskaya I. Impact and management of warm autoimmune haemolytic[...]

Sudden cardiac arrest: Limitations in risk-stratification and treatment, and the potential for digital technologies and artificial intelligence to improve prediction and outcomes

Srivats S, Zghyer F, Shahrori Z, Albert C, Al-Khatib SM, Chugh S, Etheridge SP, Goldberger ZD, Gopinathannair R, Lakkireddy D, Morin DP, Perez MV, Rottmann[...]