A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells

By sjmartinez • March 26, 2025

Chen X, Tang X, Xie Y, Cuffari BJ, Tang C, Cao F, Gao X, Meng Z, Noble PW, Young MR, Turk OM, Shirali A, Gera J, Nishimura RN, Zhou J, Hansen JE. A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells. Sci Signal. 2025 Mar 25;18(879):eadk3320. doi: 10.1126/scisignal.adk3320. Epub 2025 Mar 25. PMID: 40132052.

Tags: Hematology/Oncology, Publications, Veterans Administration

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