Mitochondrial reactive oxygen species regulate acetyl-CoA flux between cytokine production and fatty acid synthesis in effector T cells

By sjmartinez • March 17, 2025

Wu B, Woo JS, Hasiakos S, Pan C, Cokus S, Benincá C, Stiles L, Sun Z, Pellegrini M, Shirihai OS, Lusis AJ, Srikanth S, Gwack Y. Mitochondrial reactive oxygen species regulate acetyl-CoA flux between cytokine production and fatty acid synthesis in effector T cells. Cell Rep. 2025 Mar 13;44(3):115430. doi: 10.1016/j.celrep.2025.115430. Epub ahead of print. PMID: 40088449.

Tags: Cardiology/Epi, CP: Immunology, CP: Metabolism, cytokine production, EAE, Endocrinology, histone acetylation, MICOS complex, mitochondria, mitochondrial cristae architecture, neutral lipids, Publications, reactive oxygen species, Th1 cells

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