An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns

By sjmartinez • November 14, 2024

Deal M, Kar A, Lee SHT, Alvarez M, Rajkumar S, Arasu UT, Kaminska D, Männistö V, Heinonen S, van der Kolk BW, Säiläkivi U, Saarinen T, Juuti A, Pihlajamäki J, Kaikkonen MU, Laakso M, Pietiläinen KH, Pajukanta P. An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns. Am J Hum Genet. 2024 Nov 7;111(11):2542-2560. doi: 10.1016/j.ajhg.2024.10.001. PMID: 39515300.

Tags: abdominal obesity, adipocyte hypertrophy, Cardiology/Epi, population genetics, Publications, SAT, selection, single nucleus RNA sequencing, subcutaneous adipose tissue, T-box transcription factor 15, TBX15, Thermogenesis, trans regulation, Waist-hip ratio adjusted for body mass index, WHRadjBMI

Evaluating associations of oxylipin metabolites and fatty acids with incident and prevalent type 2 diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Downie CG, Highland HM, Howard AG, Alotaibi M, Elfassy T, Cordero C, Below JE, Carnethon M, Cheng S, Daviglus M, Garcia-Bedoya O, Kaplan R, Khambaty[...]

Safety and Effectiveness of a Novel Laser-Based Intravascular Lithotripsy System for Coronary Calcium: FRACTURE Study

McEntegart M, Budrys P, Sharma S, Spratt JC, Nef H, Jefferson B, Verouden N, Corrigan FE 3rd, De Silva K, Chatterjee D, Price M, Webb[...]

Pulmonary Index of Microcirculatory Resistance: A Novel Hemodynamic Index for Invasively Assessing the Pulmonary Microvasculature

Parikh RV, Klomhaus A, Chen JY, Assi A, Bassam K, Channick R, Fearon WF, Aboulhosn J, Saggar R. Pulmonary Index of Microcirculatory Resistance: A Novel[...]