An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns

By sjmartinez • November 14, 2024

Deal M, Kar A, Lee SHT, Alvarez M, Rajkumar S, Arasu UT, Kaminska D, Männistö V, Heinonen S, van der Kolk BW, Säiläkivi U, Saarinen T, Juuti A, Pihlajamäki J, Kaikkonen MU, Laakso M, Pietiläinen KH, Pajukanta P. An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns. Am J Hum Genet. 2024 Nov 7;111(11):2542-2560. doi: 10.1016/j.ajhg.2024.10.001. PMID: 39515300.

Tags: abdominal obesity, adipocyte hypertrophy, Cardiology/Epi, population genetics, Publications, SAT, selection, single nucleus RNA sequencing, subcutaneous adipose tissue, T-box transcription factor 15, TBX15, Thermogenesis, trans regulation, Waist-hip ratio adjusted for body mass index, WHRadjBMI

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