An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns

By sjmartinez • November 14, 2024

Deal M, Kar A, Lee SHT, Alvarez M, Rajkumar S, Arasu UT, Kaminska D, Männistö V, Heinonen S, van der Kolk BW, Säiläkivi U, Saarinen T, Juuti A, Pihlajamäki J, Kaikkonen MU, Laakso M, Pietiläinen KH, Pajukanta P. An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns. Am J Hum Genet. 2024 Nov 7;111(11):2542-2560. doi: 10.1016/j.ajhg.2024.10.001. PMID: 39515300.

Tags: abdominal obesity, adipocyte hypertrophy, Cardiology/Epi, population genetics, Publications, SAT, selection, single nucleus RNA sequencing, subcutaneous adipose tissue, T-box transcription factor 15, TBX15, Thermogenesis, trans regulation, Waist-hip ratio adjusted for body mass index, WHRadjBMI

Noninvasive in vivo deoxycytidine kinase (dCK)-PET identifies tumor-draining lymph nodes upon immune checkpoint inhibitor therapy

Philippe C, Cotton J, Bowden GD, Pöschel S, Knopf P, Schörg B, Gonzalez-Menendez I, Sonanini D, Flatz L, Allen-Auerbach M, Radu CG, Czernin J, Quintanilla-Martinez[...]

Design and Rationale of the WARRIOR Ancillary Study for Coronary CT Angiographic Analysis

Tamarappoo B, Wolny R, Tomasino GF, Berman D, Handberg E, Pepine CJ, Lo MC, Budoff M, Shaw L, Shufelt C, Wei J, Gulati M, Merz[...]

Ethnic differences in left ventricular myocardial volume assessed by coronary computed tomography angiography in asymptomatic adults

Zahraee S, Beshoy I, Kinninger A, Mao SS, Budoff MJ. Ethnic differences in left ventricular myocardial volume assessed by coronary computed tomography angiography in asymptomatic[...]